GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12107539 | 1 | rs66927386 | chr3:151018968 | P2RY14 | chr3:150929905-150996230:- | -0.2 | -4.35 | 1.68E-5 | Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) |
| THCA | cis | rs6695352 | 1 | rs6695352 | chr1:214954939 | KCNK2 | chr1:215178885-215410435:+ | 0.2 | 4.4 | 1.35E-5 | Migraine without aura |
| THCA | cis | rs2275426 | 1 | rs6695809 | chr1:46285461 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.24E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6695809 | chr1:46285461 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.54E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6695809 | chr1:46285461 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.28E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6695809 | chr1:46285461 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.97E-16 | Body mass index |
| THCA | cis | rs6684514 | 1 | rs66965793 | chr1:156285814 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 5.55 | 4.68E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs66965793 | chr1:156285814 | C1orf85 | chr1:156259882-156265449:- | -0.17 | -4.16 | 3.82E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs66965793 | chr1:156285814 | CCT3 | chr1:156278752-156308195:- | -0.33 | -7.21 | 2.16E-12 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs477895 | 1 | rs66968227 | chr11:64070930 | PRDX5 | chr11:64085569-64089282:+ | -0.18 | -4.53 | 7.56E-6 | Mean platelet volume |
| THCA | cis | rs11825709 | 1 | rs66977226 | chr11:93704937 | HEPHL1 | chr11:93754378-93847374:+ | 0.48 | 3.87 | 0.000126 | Obesity-related traits |
| THCA | cis | rs7551345 | 1 | rs6698579 | chr1:31861710 | ZCCHC17 | chr1:31769842-31837780:+ | -0.3 | -5.66 | 2.61E-8 | Schizophrenia |
| THCA | cis | rs73201462 | 1 | rs66987356 | chr3:127841098 | EEFSEC | chr3:127872313-128127488:+ | -0.25 | -4.37 | 1.5E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs755109 | 1 | rs66990486 | chr9:100680919 | C9orf156 | chr9:100666772-100684852:- | -0.13 | -3.48 | 0.000538 | Quantitative traits |
| THCA | cis | rs7551732 | 1 | rs6699417 | chr1:89123443 | CCBL2 | chr1:89401456-89458643:- | -0.62 | -13.76 | 1.55E-36 | Height |